Description

High‑Purity Human Menopausal Gonadotropin for Research

HMG 75 IU (Human Menopausal Gonadotropin) is a purified preparation containing a standardized 1:1 ratio of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). It is one of the most extensively studied gonadotropin preparations in reproductive endocrinology. At china grey peptides company, we supply wholesale HMG 75 IU with verified >99% purity to research facilities across the USA, Canada, the United Kingdom, and Europe. This guide covers its mechanism, research applications, purity requirements, and safe handling – so you can make an informed wholesale purchase.

What Is HMG 75 IU? (Mechanism of Action)

Human Menopausal Gonadotropin (HMG) is a gonadotropin preparation extracted from the urine of postmenopausal women, where FSH and LH production is naturally elevated. Modern HMG preparations contain 75 IU of FSH and 75 IU of LH per vial – a balanced 1:1 ratio that provides comprehensive stimulation of gonadal tissues. The first clinically usable form of HMG was isolated by Piero Donini in 1949 and introduced into use by Bruno Lunenfeld in 1961. Today, highly purified HMG (HP-hMG) is suitable for precise laboratory handling.

The mechanism of action follows the two-cell, two‑gonadotropin model of follicular steroidogenesis:

• FSH targets granulosa cells in the ovaries, promoting follicular development and estrogen production

• LH acts on theca cells, stimulating androgen production (androstenedione and testosterone)

• Together, they drive follicular growth, steroidogenesis, and – when combined with appropriate triggers – ovulation.

Upon administration, HMG binds to FSH and LH receptors on target cells, activating cyclic adenosine monophosphate (cAMP) signaling pathways. This triggers a cascade leading to follicular growth, maturation, and eventual ovulation in appropriate models. The balanced FSH and LH content provides comprehensive gonadotropic stimulation, often resulting in more physiological hormone profiles compared to single-hormone preparations.

Pharmacokinetically, HMG demonstrates excellent bioavailability when administered subcutaneously or intramuscularly. Peak serum concentrations are typically achieved within 12-24 hours, with a half‑life ranging from 24-36 hours – allowing for convenient dosing schedules.